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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.plaphy.2014.04.002
|2 doi
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|a pubmed24n0793.xml
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|a (DE-627)NLM237868482
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|a (NLM)24787501
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|a (PII)S0981-9428(14)00136-3
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Kim, Yongho
|e verfasserin
|4 aut
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| 245 |
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|a Bcl-2 suppresses activation of VPEs by inhibiting cytosolic Ca²⁺ level with elevated K⁺ efflux in NaCl-induced PCD in rice
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 15.01.2015
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 Elsevier Masson SAS. All rights reserved.
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|a Bcl-2 is one of the most important antiapoptotic members in mammals and prevents many forms of apoptosis in a variety of cell types. Our previous study revealed that overexpression of Bcl-2 significantly suppressed H2O2/NaCl-induced programmed cell death via inhibiting the transcriptional activation of OsVPE2 and OsVPE3 in transgenic rice. However, Ca(2+) and K(+) homeostasis of this process remains largely unknown. In the present study, we investigate whether nonselective cation channels (NSCC) blockers affect Bcl-2 function in rice under salt stress and how Bcl-2 affects ion homeostasis in salt stress-induced PCD. The results showed that overexpression of Bcl-2 significantly decreased transient elevations in the cytosolic Ca(2+) levels, inhibited NaCl-induced K(+) efflux but not H(+) efflux across the plasma membrane, and further suppressed the expression levels of OsVPE2 and OsVPE3, leading to the inhibition of salt-induced PCD and increase of tolerance to salt stress in transgenic rice. During the NaCl-induced PCD, the effects of a NSCC blocker La(3+) on ion homeostasis and VPEs expression in wild-type were similar to the effects of Bcl-2 overexpression in transgenic line. However, a synergistic effect of Bcl-2 and La(3+) was not obviously detectable. Our results suggested that Bcl-2 played an important role in suppression of NaCl-induced PCD by disruption of ion homeostasis, providing an insight into the mechanistic study of plant VPEs, cytosolic Ca(2+) level and K(+) efflux
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Bcl-2
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|a Cytosolic Ca(2+)
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|a K(+) efflux
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|a NaCl stress
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|a Programmed cell death
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|a Transgenic rice
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|a Vacuolar processing enzyme
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|a Proto-Oncogene Proteins c-bcl-2
|2 NLM
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|a Sodium Chloride
|2 NLM
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| 650 |
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|a 451W47IQ8X
|2 NLM
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| 650 |
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|a Potassium
|2 NLM
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|a RWP5GA015D
|2 NLM
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|a Calcium
|2 NLM
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| 650 |
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|a SY7Q814VUP
|2 NLM
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| 700 |
1 |
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|a Wang, Mingqiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bai, Yu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zeng, Zhanghui
|e verfasserin
|4 aut
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| 700 |
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|a Guo, Fu
|e verfasserin
|4 aut
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| 700 |
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|a Han, Ning
|e verfasserin
|4 aut
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| 700 |
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|a Bian, Hongwu
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Junhui
|e verfasserin
|4 aut
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| 700 |
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|a Pan, Jianwei
|e verfasserin
|4 aut
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| 700 |
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|a Zhu, Muyuan
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Plant physiology and biochemistry : PPB
|d 1991
|g 80(2014) vom: 30. Juli, Seite 168-75
|w (DE-627)NLM098178261
|x 1873-2690
|7 nnns
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| 773 |
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|g volume:80
|g year:2014
|g day:30
|g month:07
|g pages:168-75
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|u http://dx.doi.org/10.1016/j.plaphy.2014.04.002
|3 Volltext
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|d 80
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|h 168-75
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