Association between excess body weight and urine protein concentration in healthy dogs

Association between excess body weight and urine protein concentration in healthy dogs

© 2014 American Society for Veterinary Clinical Pathology and European Society for Veterinary Clinical Pathology.

Bibliographische Detailangaben
Veröffentlicht in:Veterinary clinical pathology. - 1975. - 43(2014), 2 vom: 14. Juni, Seite 255-60
1. Verfasser: Tefft, Karen M (VerfasserIn)
Weitere Verfasser: Shaw, Darcy H, Ihle, Sherri L, Burton, Shelley A, Pack, LeeAnn
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Veterinary clinical pathology
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Body condition score canine microalbuminuria obesity-related glomerulopathy urine protein:creatinine ratio Creatinine AYI8EX34EU
Beschreibung
Zusammenfassung:© 2014 American Society for Veterinary Clinical Pathology and European Society for Veterinary Clinical Pathology.
BACKGROUND: Markedly overweight people can develop progressive proteinuria and kidney failure secondary to obesity-related glomerulopathy (ORG). Glomerular lesions in dogs with experimentally induced obesity are similar to those in people with ORG
OBJECTIVES: The aim of this study was to evaluate if urine protein and albumin excretion is greater in overweight and obese dogs than in dogs of ideal body condition
METHODS: Client-owned dogs were screened for underlying health conditions. These dogs were assigned a body condition score (BCS) using a 9-point scoring system. Dogs with a BCS of ≥ 6 were classified as being overweight/obese, and dogs with a BCS of 4 or 5 were classified as being of ideal body weight. The urine protein:creatinine ratio (UPC) and urine albumin:creatinine ratio (UAC) were then determined, and compared between 20 overweight/obese dogs and 22 ideal body weight control dogs
RESULTS: Median UPC (0.04 [range, 0.01-0.14; interquartile range, 0.07]) and UAC (0.41 [0-10.39; 3.21]) of overweight/obese dogs were not significantly different from median UPC (0.04 [0.01-0.32; 0.07]) and UAC (0.18 [0-7.04; 1.75]) in ideal body weight dogs
CONCLUSIONS: Clinicopathologic abnormalities consistent with ORG were absent from overweight/obese dogs in this study
Beschreibung:Date Completed 16.04.2015
Date Revised 20.10.2016
published: Print-Electronic
Citation Status MEDLINE
ISSN:1939-165X
DOI:10.1111/vcp.12139