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20231224101659.0 |
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231224s2014 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1016/j.clim.2013.12.005
|2 doi
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| 028 |
5 |
2 |
|a pubmed24n0782.xml
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|a (DE-627)NLM234629487
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|a (NLM)24440646
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|a (PII)S1521-6616(13)00324-0
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Bere, Alfred
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Altered phenotype and function of NK cells infiltrating human papillomavirus (HPV)-associated genital warts during HIV infection
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| 264 |
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1 |
|c 2014
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 08.04.2014
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| 500 |
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|a Date Revised 05.02.2014
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| 500 |
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|a published: Print-Electronic
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2013 Elsevier Inc. All rights reserved.
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| 520 |
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|a HIV-infected individuals experience more persistent HPV infections and are less likely to resolve genital warts. This study compared phenotype and functions of NK and T cells from genital warts and blood from 67 women. We compared in vitro functional responses of NK and T cells by multiparametric flow cytometry. HIV+ women had significantly lower frequencies of CD4 T cells in warts (p = 0.001) and blood (p = 0.001). While the distribution of NK cell subsets was similar, HIV+ women tended to have lower frequencies of CD56(Dim) NK cells in both blood (p = 0.0001) and warts (p = 0.006) than HIV- women. Wart NK cells from HIV+ women expressed significantly lower CD107a and produced IFN-γ. HAART status was not associated with differences in NK cell functionality. We conclude that wart NK cells from HIV+ women have defects in their ability to degranulate and/or secrete IFN-γ, which may provide insights into why HIV+ women fail to spontaneously resolve genital warts
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, N.I.H., Extramural
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Genital warts;
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| 650 |
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4 |
|a HIV;
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| 650 |
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4 |
|a HPV;
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| 650 |
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4 |
|a Mucosal;
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| 650 |
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4 |
|a NK cells
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Tayib, Shahila
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kriek, Jean-Mari
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Masson, Lindi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jaumdally, Shameem Z
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Barnabas, Shaun L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Carr, William H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Allan, Bruce
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Williamson, Anna-Lise
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Denny, Lynette
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Passmore, Jo-Ann S
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 150(2014), 2 vom: 10. Feb., Seite 210-9
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:150
|g year:2014
|g number:2
|g day:10
|g month:02
|g pages:210-9
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2013.12.005
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 150
|j 2014
|e 2
|b 10
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|h 210-9
|