Altered phenotype and function of NK cells infiltrating human papillomavirus (HPV)-associated genital warts during HIV infection

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 150(2014), 2 vom: 10. Feb., Seite 210-9
1. Verfasser:	Bere, Alfred (VerfasserIn)
Weitere Verfasser:	Tayib, Shahila, Kriek, Jean-Mari, Masson, Lindi, Jaumdally, Shameem Z, Barnabas, Shaun L, Carr, William H, Allan, Bruce, Williamson, Anna-Lise, Denny, Lynette, Passmore, Jo-Ann S
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2014
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Genital warts; HIV; HPV; Mucosal; NK cells Interferon-gamma 82115-62-6

Beschreibung
Zusammenfassung:	Copyright © 2013 Elsevier Inc. All rights reserved. HIV-infected individuals experience more persistent HPV infections and are less likely to resolve genital warts. This study compared phenotype and functions of NK and T cells from genital warts and blood from 67 women. We compared in vitro functional responses of NK and T cells by multiparametric flow cytometry. HIV+ women had significantly lower frequencies of CD4 T cells in warts (p = 0.001) and blood (p = 0.001). While the distribution of NK cell subsets was similar, HIV+ women tended to have lower frequencies of CD56(Dim) NK cells in both blood (p = 0.0001) and warts (p = 0.006) than HIV- women. Wart NK cells from HIV+ women expressed significantly lower CD107a and produced IFN-γ. HAART status was not associated with differences in NK cell functionality. We conclude that wart NK cells from HIV+ women have defects in their ability to degranulate and/or secrete IFN-γ, which may provide insights into why HIV+ women fail to spontaneously resolve genital warts
Beschreibung:	Date Completed 08.04.2014 Date Revised 05.02.2014 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2013.12.005