Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines

Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines

Copyright © 2013 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 150(2014), 1 vom: 01. Jan., Seite 90-100
1. Verfasser: Esnault, Stephane (VerfasserIn)
Weitere Verfasser: Kelly, Elizabeth A, Johansson, Mats W, Liu, Lin Ying, Han, Shih-Tsung, Akhtar, Moneeb, Sandbo, Nathan, Mosher, Deane F, Denlinger, Loren C, Mathur, Sameer K, Malter, James S, Jarjour, Nizar N
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural BAL EOS Eosinophil Fibrosis IL-3 RT-qPCR SBP-Ag Sema7a mehr... Semaphorin 7A Translation bronchoalveolar lavage eosinophils real-time quantitative PCR segmental bronchoprovocation with allergen semaphorin 7A. ACTA2 protein, human Actins Allergens Antigens, CD GPI-Linked Proteins IL5 protein, human Interleukin-5 SEMA7A protein, human Semaphorins
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100 1 |a Esnault, Stephane  |e verfasserin  |4 aut 
245 1 0 |a Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines 
264 1 |c 2014 
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500 |a Date Revised 21.10.2021 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2013 Elsevier Inc. All rights reserved. 
520 |a Semaphorin 7A (sema7a) plays a major role in TGF-β1-induced lung fibrosis. Based on the accumulating evidence that eosinophils contribute to fibrosis/remodeling in the airway, we hypothesized that airway eosinophils may be a significant source of sema7a. In vivo, sema7a was expressed on the surface of circulating eosinophils and upregulated on bronchoalveolar lavage eosinophils obtained after segmental bronchoprovocation with allergen. Based on mRNA levels in unfractionated and isolated bronchoalveolar cells, eosinophils are the predominant source of sema7a. In vitro, among the members of the IL-5-family cytokines, sema7a protein on the surface of blood eosinophils was increased more by IL-3 than by GM-CSF or IL-5. Cytokine-induced expression of cell surface sema7a required translation of newly synthesized protein. Finally, a recombinant sema7a induced alpha-smooth muscle actin production in human bronchial fibroblasts. semaphorin 7A is a potentially important modulator of eosinophil profibrotic functions in the airway remodeling of patients with chronic asthma 
650 4 |a Journal Article 
650 4 |a Research Support, N.I.H., Extramural 
650 4 |a BAL 
650 4 |a EOS 
650 4 |a Eosinophil 
650 4 |a Fibrosis 
650 4 |a IL-3 
650 4 |a RT-qPCR 
650 4 |a SBP-Ag 
650 4 |a Sema7a 
650 4 |a Semaphorin 7A 
650 4 |a Translation 
650 4 |a bronchoalveolar lavage 
650 4 |a eosinophils 
650 4 |a real-time quantitative PCR 
650 4 |a segmental bronchoprovocation with allergen 
650 4 |a semaphorin 7A. 
650 7 |a ACTA2 protein, human  |2 NLM 
650 7 |a Actins  |2 NLM 
650 7 |a Allergens  |2 NLM 
650 7 |a Antigens, CD  |2 NLM 
650 7 |a GPI-Linked Proteins  |2 NLM 
650 7 |a IL5 protein, human  |2 NLM 
650 7 |a Interleukin-5  |2 NLM 
650 7 |a SEMA7A protein, human  |2 NLM 
650 7 |a Semaphorins  |2 NLM 
700 1 |a Kelly, Elizabeth A  |e verfasserin  |4 aut 
700 1 |a Johansson, Mats W  |e verfasserin  |4 aut 
700 1 |a Liu, Lin Ying  |e verfasserin  |4 aut 
700 1 |a Han, Shih-Tsung  |e verfasserin  |4 aut 
700 1 |a Akhtar, Moneeb  |e verfasserin  |4 aut 
700 1 |a Sandbo, Nathan  |e verfasserin  |4 aut 
700 1 |a Mosher, Deane F  |e verfasserin  |4 aut 
700 1 |a Denlinger, Loren C  |e verfasserin  |4 aut 
700 1 |a Mathur, Sameer K  |e verfasserin  |4 aut 
700 1 |a Malter, James S  |e verfasserin  |4 aut 
700 1 |a Jarjour, Nizar N  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Clinical immunology (Orlando, Fla.)  |d 1999  |g 150(2014), 1 vom: 01. Jan., Seite 90-100  |w (DE-627)NLM098196855  |x 1521-7035  |7 nnns 
773 1 8 |g volume:150  |g year:2014  |g number:1  |g day:01  |g month:01  |g pages:90-100 
856 4 0 |u http://dx.doi.org/10.1016/j.clim.2013.11.009  |3 Volltext 
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