Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines

Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines

Copyright © 2013 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 150(2014), 1 vom: 01. Jan., Seite 90-100
1. Verfasser: Esnault, Stephane (VerfasserIn)
Weitere Verfasser: Kelly, Elizabeth A, Johansson, Mats W, Liu, Lin Ying, Han, Shih-Tsung, Akhtar, Moneeb, Sandbo, Nathan, Mosher, Deane F, Denlinger, Loren C, Mathur, Sameer K, Malter, James S, Jarjour, Nizar N
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural BAL EOS Eosinophil Fibrosis IL-3 RT-qPCR SBP-Ag Sema7a mehr... Semaphorin 7A Translation bronchoalveolar lavage eosinophils real-time quantitative PCR segmental bronchoprovocation with allergen semaphorin 7A. ACTA2 protein, human Actins Allergens Antigens, CD GPI-Linked Proteins IL5 protein, human Interleukin-5 SEMA7A protein, human Semaphorins
Beschreibung
Zusammenfassung:Copyright © 2013 Elsevier Inc. All rights reserved.
Semaphorin 7A (sema7a) plays a major role in TGF-β1-induced lung fibrosis. Based on the accumulating evidence that eosinophils contribute to fibrosis/remodeling in the airway, we hypothesized that airway eosinophils may be a significant source of sema7a. In vivo, sema7a was expressed on the surface of circulating eosinophils and upregulated on bronchoalveolar lavage eosinophils obtained after segmental bronchoprovocation with allergen. Based on mRNA levels in unfractionated and isolated bronchoalveolar cells, eosinophils are the predominant source of sema7a. In vitro, among the members of the IL-5-family cytokines, sema7a protein on the surface of blood eosinophils was increased more by IL-3 than by GM-CSF or IL-5. Cytokine-induced expression of cell surface sema7a required translation of newly synthesized protein. Finally, a recombinant sema7a induced alpha-smooth muscle actin production in human bronchial fibroblasts. semaphorin 7A is a potentially important modulator of eosinophil profibrotic functions in the airway remodeling of patients with chronic asthma
Beschreibung:Date Completed 11.03.2014
Date Revised 21.10.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2013.11.009