Substrates with patterned extracellular matrix and subcellular stiffness gradients reveal local biomechanical responses
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
| Veröffentlicht in: | Advanced materials (Deerfield Beach, Fla.). - 1998. - 26(2014), 8 vom: 26. Feb., Seite 1242-7 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
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2014
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| Zugriff auf das übergeordnete Werk: | Advanced materials (Deerfield Beach, Fla.) |
| Schlagworte: | Journal Article Research Support, N.I.H., Extramural BioMEMS biomechanics cell control mechanotransduction stress fibers Actins Culture Media Dimethylpolysiloxanes mehr... |
| Zusammenfassung: | © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. A substrate fabrication process is developed to pattern both the extracellular matrix (ECM) and rigidity at sub-cellular spatial resolution. When growing cells on these substrates, it is found that cells respond locally in their cytoskeleton assembly. The presented method allows unique insight into the biological interpretation of mechanical signals, whereas photolithography-based fabrication is amenable to integration with complex microfabricated substructures |
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| Beschreibung: | Date Completed 03.12.2014 Date Revised 21.03.2024 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-4095 |
| DOI: | 10.1002/adma.201304607 |