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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2013.09.002
|2 doi
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|a eng
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1 |
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|a Amarilyo, Gil
|e verfasserin
|4 aut
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|a Leptin promotes lupus T-cell autoimmunity
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|c 2013
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|a Text
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|a Date Completed 30.12.2013
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|a Date Revised 03.12.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2013.
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|a In systemic lupus erythematosus (SLE), the impairment in apoptosis can facilitate the initiation and maintenance of autoimmune responses to self antigens. Here we show that the adipocytokine leptin, which is abnormally elevated in SLE, promotes the survival and proliferation of autoreactive T-cells in mice with an autoreactive T-cell repertoire, including (NZB x NZW)F1 lupus-prone mice. This ability of leptin to promote lupus T-cell autoimmunity suggests the possibility of a therapeutic targeting of leptin in SLE
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|a Journal Article
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|a Apoptosis
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|a Autoimmunity
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| 650 |
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4 |
|a Autoreactive T cells
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| 650 |
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4 |
|a Systemic lupus erythematosus
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| 650 |
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7 |
|a Autoantibodies
|2 NLM
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| 650 |
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|a Leptin
|2 NLM
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| 650 |
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|a Dexamethasone
|2 NLM
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| 650 |
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|a 7S5I7G3JQL
|2 NLM
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| 700 |
1 |
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|a Iikuni, Noriko
|e verfasserin
|4 aut
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1 |
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|a Shi, Fu-Dong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Aijing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Matarese, Giuseppe
|e verfasserin
|4 aut
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| 700 |
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|a La Cava, Antonio
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 149(2013), 3 vom: 14. Dez., Seite 530-3
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|g volume:149
|g year:2013
|g number:3
|g day:14
|g month:12
|g pages:530-3
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|u http://dx.doi.org/10.1016/j.clim.2013.09.002
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