Leptin promotes lupus T-cell autoimmunity

Leptin promotes lupus T-cell autoimmunity

© 2013.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 149(2013), 3 vom: 14. Dez., Seite 530-3
1. Verfasser: Amarilyo, Gil (VerfasserIn)
Weitere Verfasser: Iikuni, Noriko, Shi, Fu-Dong, Liu, Aijing, Matarese, Giuseppe, La Cava, Antonio
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Apoptosis Autoimmunity Autoreactive T cells Systemic lupus erythematosus Autoantibodies Leptin Dexamethasone 7S5I7G3JQL
Beschreibung
Zusammenfassung:© 2013.
In systemic lupus erythematosus (SLE), the impairment in apoptosis can facilitate the initiation and maintenance of autoimmune responses to self antigens. Here we show that the adipocytokine leptin, which is abnormally elevated in SLE, promotes the survival and proliferation of autoreactive T-cells in mice with an autoreactive T-cell repertoire, including (NZB x NZW)F1 lupus-prone mice. This ability of leptin to promote lupus T-cell autoimmunity suggests the possibility of a therapeutic targeting of leptin in SLE
Beschreibung:Date Completed 30.12.2013
Date Revised 03.12.2013
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2013.09.002