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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1107/S0909049513021596
|2 doi
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|a pubmed25n0772.xml
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|a (DE-627)NLM231658486
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|a (NLM)24121350
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|a DE-627
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|a eng
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|a Takahashi, Sachiko
|e verfasserin
|4 aut
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|a JAXA protein crystallization in space
|b ongoing improvements for growing high-quality crystals
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 22.05.2014
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The Japan Aerospace Exploration Agency (JAXA) started a high-quality protein crystal growth project, now called JAXA PCG, on the International Space Station (ISS) in 2002. Using the counter-diffusion technique, 14 sessions of experiments have been performed as of 2012 with 580 proteins crystallized in total. Over the course of these experiments, a user-friendly interface framework for high accessibility has been constructed and crystallization techniques improved; devices to maximize the use of the microgravity environment have been designed, resulting in some high-resolution crystal growth. If crystallization conditions were carefully fixed in ground-based experiments, high-quality protein crystals grew in microgravity in many experiments on the ISS, especially when a highly homogeneous protein sample and a viscous crystallization solution were employed. In this article, the current status of JAXA PCG is discussed, and a rational approach to high-quality protein crystal growth in microgravity based on numerical analyses is explained
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|a Journal Article
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|a JAXA
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|a Japan Experiment Module `Kibo'
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|a counter-diffusion
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|a impurity depletion zone
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|a microgravity
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|a protein crystal
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|a protein depletion zone
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|a Proteins
|2 NLM
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|a Ohta, Kazunori
|e verfasserin
|4 aut
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|a Furubayashi, Naoki
|e verfasserin
|4 aut
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|a Yan, Bin
|e verfasserin
|4 aut
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|a Koga, Misako
|e verfasserin
|4 aut
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|a Wada, Yoshio
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yamada, Mitsugu
|e verfasserin
|4 aut
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|a Inaka, Koji
|e verfasserin
|4 aut
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|a Tanaka, Hiroaki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Miyoshi, Hiroshi
|e verfasserin
|4 aut
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| 700 |
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|a Kobayashi, Tomoyuki
|e verfasserin
|4 aut
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|a Kamigaichi, Shigeki
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of synchrotron radiation
|d 1994
|g 20(2013), Pt 6 vom: 07. Nov., Seite 968-73
|w (DE-627)NLM09824129X
|x 1600-5775
|7 nnns
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| 773 |
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|g volume:20
|g year:2013
|g number:Pt 6
|g day:07
|g month:11
|g pages:968-73
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|u http://dx.doi.org/10.1107/S0909049513021596
|3 Volltext
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|h 968-73
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