Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors

Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors

© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 25(2013), 39 vom: 18. Okt., Seite 5609-14
1. Verfasser: Shen, Yuefei (VerfasserIn)
Weitere Verfasser: Zhang, Shiyi, Zhang, Fuwu, Loftis, Alexander, Pavía-Sanders, Adriana, Zou, Jiong, Fan, Jingwei, Taylor, John-Stephen A, Wooley, Karen L
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. degradation iNOS inhibition integrated construction polyphosphoester-based nanoparticle Enzyme Inhibitors Esters Polymers mehr... Nitric Oxide 31C4KY9ESH Nitric Oxide Synthase Type II EC 1.14.13.39
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245 1 0 |a Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors 
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500 |a Date Revised 10.06.2024 
500 |a published: Print-Electronic 
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520 |a A degradable polyphosphoester (PPE)-based cationic nanoparticle (cSCK), which is integrated constructed as a novel degradable drug device, demonstrates surprisingly efficient inhibition of inducible nitric oxide synthase (iNOS) transcription, and eventually inhibits nitric oxide (NO) over-production, without loading of any specific therapeutic drugs. This system may serve as a promising anti-inflammatory agent toward the treatment of acute lung injury 
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650 4 |a Research Support, N.I.H., Extramural 
650 4 |a Research Support, U.S. Gov't, Non-P.H.S. 
650 4 |a degradation 
650 4 |a iNOS inhibition 
650 4 |a integrated construction 
650 4 |a polyphosphoester-based nanoparticle 
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700 1 |a Zhang, Shiyi  |e verfasserin  |4 aut 
700 1 |a Zhang, Fuwu  |e verfasserin  |4 aut 
700 1 |a Loftis, Alexander  |e verfasserin  |4 aut 
700 1 |a Pavía-Sanders, Adriana  |e verfasserin  |4 aut 
700 1 |a Zou, Jiong  |e verfasserin  |4 aut 
700 1 |a Fan, Jingwei  |e verfasserin  |4 aut 
700 1 |a Taylor, John-Stephen A  |e verfasserin  |4 aut 
700 1 |a Wooley, Karen L  |e verfasserin  |4 aut 
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773 1 8 |g volume:25  |g year:2013  |g number:39  |g day:18  |g month:10  |g pages:5609-14 
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