Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors

Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors

© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 25(2013), 39 vom: 18. Okt., Seite 5609-14
1. Verfasser: Shen, Yuefei (VerfasserIn)
Weitere Verfasser: Zhang, Shiyi, Zhang, Fuwu, Loftis, Alexander, Pavía-Sanders, Adriana, Zou, Jiong, Fan, Jingwei, Taylor, John-Stephen A, Wooley, Karen L
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. degradation iNOS inhibition integrated construction polyphosphoester-based nanoparticle Enzyme Inhibitors Esters Polymers mehr... Nitric Oxide 31C4KY9ESH Nitric Oxide Synthase Type II EC 1.14.13.39
Beschreibung
Zusammenfassung:© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
A degradable polyphosphoester (PPE)-based cationic nanoparticle (cSCK), which is integrated constructed as a novel degradable drug device, demonstrates surprisingly efficient inhibition of inducible nitric oxide synthase (iNOS) transcription, and eventually inhibits nitric oxide (NO) over-production, without loading of any specific therapeutic drugs. This system may serve as a promising anti-inflammatory agent toward the treatment of acute lung injury
Beschreibung:Date Completed 14.05.2014
Date Revised 10.06.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201302842