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NLM225091089 |
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231224s2013 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2013.01.005
|2 doi
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|a pubmed25n0750.xml
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|a (DE-627)NLM225091089
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|a (NLM)23416240
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|a (PII)S1521-6616(13)00016-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Bay, Jakob T
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Pre-transplant levels of ficolin-3 are associated with kidney graft survival
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| 264 |
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1 |
|c 2013
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 23.04.2013
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|a Date Revised 04.03.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2013 Elsevier Inc. All rights reserved.
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|a Ficolin-3 is an initiator of the lectin complement pathway. The complement system is a mediator of the pathophysiology of graft rejection in kidney transplantation, but the role of ficolin-3 in this process is unknown. Using a prospective study design, 527 kidney transplanted patients were included. 97 blood donors served as controls. Ficolin-3, C4 and C3 were measured in pre-transplant as well as in control serum samples. In controls, deposition of ficolin-3, C4, C3 and the terminal complement complex (TCC) was measured in an assay based on acetylated albumin as matrix. The ficolin-3 levels correlated with the serum levels of C4 and C3. The serum levels of ficolin-3 correlated with the deposition of ficolin-3, C4, C3 and TCC. Survival analyses showed that high pre-transplant serum levels of ficolin-3 were associated with decreased graft survival. These results suggest an important role of ficolin-3 in the pathophysiology of kidney graft rejection
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a FCN3 protein, human
|2 NLM
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| 650 |
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7 |
|a Glycoproteins
|2 NLM
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| 650 |
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7 |
|a Lectins
|2 NLM
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| 650 |
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|a Complement System Proteins
|2 NLM
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| 650 |
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|a 9007-36-7
|2 NLM
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| 700 |
1 |
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|a Hein, Estrid
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sørensen, Søren S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hansen, Jesper Melchior
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Garred, Peter
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 146(2013), 3 vom: 01. März, Seite 240-7
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:146
|g year:2013
|g number:3
|g day:01
|g month:03
|g pages:240-7
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2013.01.005
|3 Volltext
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