Modular 'click-in-emulsion' bone-targeted nanogels

Modular 'click-in-emulsion' bone-targeted nanogels

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 25(2013), 10 vom: 13. März, Seite 1449-54
1. Verfasser: Heller, Daniel A (VerfasserIn)
Weitere Verfasser: Levi, Yair, Pelet, Jeisa M, Doloff, Joshua C, Wallas, Jasmine, Pratt, George W, Jiang, Shan, Sahay, Gaurav, Schroeder, Avi, Schroeder, Josh E, Chyan, Yieu, Zurenko, Christopher, Querbes, William, Manzano, Miguel, Kohane, Daniel S, Langer, Robert, Anderson, Daniel G
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
Beschreibung
Zusammenfassung:Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects
Beschreibung:Date Completed 03.09.2013
Date Revised 10.06.2024
published: Print-Electronic
Citation Status PubMed-not-MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201202881