Effects of urea on selectivity and protein-ligand interactions in multimodal cation exchange chromatography
Nuclear magnetic resonance (NMR) and molecular dynamics (MD) simulations were employed in concert with chromatography to provide insight into the effect of urea on protein-ligand interactions in multimodal (MM) chromatography. Chromatographic experiments with a protein library in ion exchange (IEX)...
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Détails bibliographiques
Publié dans: | Langmuir : the ACS journal of surfaces and colloids. - 1985. - 29(2013), 1 vom: 08. Jan., Seite 158-67
|
Auteur principal: |
Holstein, Melissa A
(Auteur) |
Autres auteurs: |
Parimal, Siddharth,
McCallum, Scott A,
Cramer, Steven M |
Format: | Article en ligne
|
Langue: | English |
Publié: |
2013
|
Accès à la collection: | Langmuir : the ACS journal of surfaces and colloids
|
Sujets: | Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Ligands
Proteins
Ubiquitin
Urea
8W8T17847W |