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20231224050035.0 |
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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201201484
|2 doi
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|a pubmed24n0735.xml
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|a (DE-627)NLM220688397
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|a (NLM)22941789
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|a DE-627
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|e rakwb
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|a eng
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1 |
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|a Nakatsuka, Matthew A
|e verfasserin
|4 aut
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|a Aptamer-crosslinked microbubbles
|b smart contrast agents for thrombin-activated ultrasound imaging
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 01.05.2013
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Aptamers, Nucleotide
|2 NLM
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| 650 |
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|a Contrast Media
|2 NLM
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|a Cross-Linking Reagents
|2 NLM
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| 650 |
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|a Thrombin
|2 NLM
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| 650 |
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|a EC 3.4.21.5
|2 NLM
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| 700 |
1 |
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|a Mattrey, Robert F
|e verfasserin
|4 aut
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1 |
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|a Esener, Sadik C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cha, Jennifer N
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Goodwin, Andrew P
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 24(2012), 45 vom: 27. Nov., Seite 6010-6
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|x 1521-4095
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|g volume:24
|g year:2012
|g number:45
|g day:27
|g month:11
|g pages:6010-6
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|u http://dx.doi.org/10.1002/adma.201201484
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