Aptamer-crosslinked microbubbles smart contrast agents for thrombin-activated ultrasound imaging

Aptamer-crosslinked microbubbles : smart contrast agents for thrombin-activated ultrasound imaging

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 24(2012), 45 vom: 27. Nov., Seite 6010-6
1. Verfasser: Nakatsuka, Matthew A (VerfasserIn)
Weitere Verfasser: Mattrey, Robert F, Esener, Sadik C, Cha, Jennifer N, Goodwin, Andrew P
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2012
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Aptamers, Nucleotide Contrast Media Cross-Linking Reagents Thrombin EC 3.4.21.5
Beschreibung
Zusammenfassung:Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles
Beschreibung:Date Completed 01.05.2013
Date Revised 21.10.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201201484