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20231224044530.0 |
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231224s2012 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1021/la302732w
|2 doi
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|a pubmed24n0733.xml
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|a (DE-627)NLM220093172
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|a (NLM)22877364
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Li, Yan
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a New bactericidal surgical suture coating
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 28.12.2012
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|a Date Revised 28.09.2017
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a This paper demonstrates the effectiveness of a new antimicrobial suture coating. An amphiphilic polymer, poly[(aminoethyl methacrylate)-co-(butyl methacrylate)] (PAMBM), inspired by antimicrobial peptides, was bactericidal against S. aureus in time-kill experiments. PAMBM was then evaluated in a variety of polymer blends using the Japanese Industrial Standard (JIS) method and showed excellent antimicrobial activity at a low concentration (0.5 wt %). Using a similar antimicrobial coating formula to commercial Vicryl Plus sutures, disk samples of the coating material containing PAMBM effectively killed bacteria (98% reduction at 0.75 wt %). Triclosan, the active ingredient in Vicryl Plus coatings, did not kill the bacteria. Further Kirby-Bauer assays of these disk samples showed an increasing zone of inhibition with increasing concentration of PAMBM. Finally, the PAMBM-containing coating was applied to sutures, and the morphology of the coating surface was characterized by SEM, along with Vicryl and uncoated sutures. The PAMBM-containing sutures killed bacteria more effectively (3 log(10) reduction at 2.4 wt %) than Vicryl Plus sutures (0.5 log(10) reduction)
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Anti-Bacterial Agents
|2 NLM
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|a Polymers
|2 NLM
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|a Stearic Acids
|2 NLM
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|a stearic acid
|2 NLM
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|a 4ELV7Z65AP
|2 NLM
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| 650 |
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|a Triclosan
|2 NLM
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| 650 |
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|a 4NM5039Y5X
|2 NLM
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| 700 |
1 |
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|a Kumar, Kushi N
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dabkowski, Jeffrey M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Corrigan, Meagan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Scott, Richard W
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nüsslein, Klaus
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tew, Gregory N
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 28(2012), 33 vom: 21. Aug., Seite 12134-9
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:28
|g year:2012
|g number:33
|g day:21
|g month:08
|g pages:12134-9
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