Inhibition of cellular efflux pumps involved in multi xenobiotic resistance (MXR) in echinoid larvae as a possible mode of action for increased ecotoxicological risk of mixtures

In marine organisms the multi xenobiotic resistance (MXR) mechanism via e.g. P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) is an important first line of defense against contaminants by pumping contaminants out of the cells. If compounds would impair the MXR mechanism, this...

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Publié dans:	Ecotoxicology (London, England). - 1992. - 21(2012), 8 vom: 07. Nov., Seite 2276-87
Auteur principal:	Anselmo, Henrique M R (Auteur)
Autres auteurs:	van den Berg, Johannes H J, Rietjens, Ivonne M C M, Murk, Albertinka J
Format:	Article en ligne
Langue:	English
Publié:	2012
Accès à la collection:	Ecotoxicology (London, England)
Sujets:	Evaluation Study Journal Article Research Support, Non-U.S. Gov't Fluoresceins Xenobiotics fluorexon V0YM2B16TS