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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1021/la3019327
|2 doi
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|a pubmed24n0729.xml
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|a (DE-627)NLM218855303
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|a (NLM)22724540
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Liebi, Marianne
|e verfasserin
|4 aut
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|a Cholesterol increases the magnetic aligning of bicellar disks from an aqueous mixture of DMPC and DMPE-DTPA with complexed thulium ions
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 30.11.2012
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm(3+)), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5-22 °C), as shown by cryo-transmission electron microscopy (cryo-TEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm(3+), allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm(3+) complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm(3+) aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Ions
|2 NLM
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|a Organometallic Compounds
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|a Water
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|a 059QF0KO0R
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|a Pentetic Acid
|2 NLM
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|a 7A314HQM0I
|2 NLM
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|a Thulium
|2 NLM
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|a 8RKC5ATI4P
|2 NLM
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|a Cholesterol
|2 NLM
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|a 97C5T2UQ7J
|2 NLM
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|a Dimyristoylphosphatidylcholine
|2 NLM
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|a U86ZGC74V5
|2 NLM
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| 700 |
1 |
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|a Kohlbrecher, Joachim
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ishikawa, Takashi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fischer, Peter
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Walde, Peter
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Windhab, Erich J
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 28(2012), 29 vom: 24. Juli, Seite 10905-15
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:28
|g year:2012
|g number:29
|g day:24
|g month:07
|g pages:10905-15
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|u http://dx.doi.org/10.1021/la3019327
|3 Volltext
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