|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM215756185 |
| 003 |
DE-627 |
| 005 |
20231224030157.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2012 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1021/la300194v
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0719.xml
|
| 035 |
|
|
|a (DE-627)NLM215756185
|
| 035 |
|
|
|a (NLM)22369236
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Izquierdo-Lorenzo, Irene
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Adsorption and detection of sport doping drugs on metallic plasmonic nanoparticles of different morphology
|
| 264 |
|
1 |
|c 2012
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 23.10.2012
|
| 500 |
|
|
|a Date Revised 21.11.2013
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a A comparative study of different plasmonic nanoparticles with different morphologies (nanospheres and triangular nanoprisms) and metals (Ag and Au) was done in this work and applied to the ultrasensitive detection of aminoglutethimide (AGI) drug by surface enhanced Raman spectroscopy (SERS) and plasmon resonance. AGI is an aromatase inhibitor used as an antitumoral drug with remarkable pharmacological interest and also in illegal sport doping. The application of very sensitive spectroscopic techniques based on the localization of an electromagnetic field on plasmonic nanoparticles confirms the previous study of the adsorption of drugs onto a metal surface due to the near field character of these techniques. The adsorption of AGI on the above substrates was investigated at different pH values and surface coverages, and the results were analyzed on the basis of AGI/metal affinity, considering the interaction mechanism, the existence of two binding sites in AGI, and the influence of the interface on the adsorption in terms of surface charge due to the presence of other ions linked to the surface. Finally, a comparative quantitative detection of AGI was performed on both spherical and triangular nanoprism nanoparticles, and a limit of detection lower than those reported so far was deduced on the latter nanoparticles
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Aminoglutethimide
|2 NLM
|
| 650 |
|
7 |
|a 0O54ZQ14I9
|2 NLM
|
| 650 |
|
7 |
|a Silver
|2 NLM
|
| 650 |
|
7 |
|a 3M4G523W1G
|2 NLM
|
| 650 |
|
7 |
|a Gold
|2 NLM
|
| 650 |
|
7 |
|a 7440-57-5
|2 NLM
|
| 700 |
1 |
|
|a Alda, Irene
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Sanchez-Cortes, Santiago
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Garcia-Ramos, José Vicente
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 28(2012), 24 vom: 19. Juni, Seite 8891-901
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
|
| 773 |
1 |
8 |
|g volume:28
|g year:2012
|g number:24
|g day:19
|g month:06
|g pages:8891-901
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/la300194v
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_721
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 28
|j 2012
|e 24
|b 19
|c 06
|h 8891-901
|