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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2012.01.003
|2 doi
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|a pubmed24n0718.xml
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|a (DE-627)NLM215489365
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|a (NLM)22341910
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Min, So-Youn
|e verfasserin
|4 aut
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| 245 |
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|a Peritoneal catheter implantation elicits IL-10-producing immune-suppressor macrophages through a MyD88-dependent pathway
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 11.05.2012
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|a Date Revised 09.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2012 Elsevier Inc. All rights reserved.
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|a Catheters are implanted into the peritoneal cavity during the process of peritoneal dialysis. Though these catheters may be effective and beneficial, the impact of catheters on the immune system is poorly understood. Catheters and other devices implanted in the peritoneal cavity elicit a foreign body reaction. However, the immunological consequences of this remain uncharacterized. To model this, catheters were implanted into the peritoneal cavity of healthy mice. Catheter implantation induced rapid cellular changes within the peritoneal cavity. Whereas B-cells and T-cells were reduced, catheter implantation was associated with the rapid expansion of F4/80-low-positive, CD11b-positive macrophages that elaborated IL-10, and suppressed T-cell division and Th1 skewing in co-culture assays. Peritoneal catheter elicited macrophages had increased Jmjd3 but reduced NF-κB activation, and their emergence was MyD88-dependent. Collectively, these studies indicate that foreign body implantation into the peritoneal cavity is associated with the expansion of suppressor macrophages. Whether peritoneal cavity catheter implantation may have systemic immunoregulatory roles remains to be explored
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Antigens, Differentiation
|2 NLM
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|a CD11b Antigen
|2 NLM
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|a CD5 Antigens
|2 NLM
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|a Myeloid Differentiation Factor 88
|2 NLM
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|a monocyte-macrophage differentiation antigen
|2 NLM
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|a Interleukin-10
|2 NLM
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|a 130068-27-8
|2 NLM
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| 650 |
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|a Jumonji Domain-Containing Histone Demethylases
|2 NLM
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| 650 |
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|a EC 1.14.11.-
|2 NLM
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| 650 |
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|a Kdm6b protein, mouse
|2 NLM
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| 650 |
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|a EC 1.5.-
|2 NLM
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| 700 |
1 |
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|a Fu, Yuyang
|e verfasserin
|4 aut
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|a Hutcheson, Jack
|e verfasserin
|4 aut
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|a Wu, Tianfu
|e verfasserin
|4 aut
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|a Khobahy, Elhaum
|e verfasserin
|4 aut
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|a Zhu, Jiankun
|e verfasserin
|4 aut
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|a Vanarsa, Kamala
|e verfasserin
|4 aut
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|a Du, Yong
|e verfasserin
|4 aut
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|a Park, Min-Jung
|e verfasserin
|4 aut
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|a Park, Hyun-Sil
|e verfasserin
|4 aut
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|a Saxena, Ramesh
|e verfasserin
|4 aut
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|a Kim, Ho-Youn
|e verfasserin
|4 aut
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| 700 |
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|a Mohan, Chandra
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 143(2012), 1 vom: 14. Apr., Seite 59-72
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:143
|g year:2012
|g number:1
|g day:14
|g month:04
|g pages:59-72
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|u http://dx.doi.org/10.1016/j.clim.2012.01.003
|3 Volltext
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