Peritoneal catheter implantation elicits IL-10-producing immune-suppressor macrophages through a MyD88-dependent pathway

Peritoneal catheter implantation elicits IL-10-producing immune-suppressor macrophages through a MyD88-dependent pathway

Copyright © 2012 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 143(2012), 1 vom: 14. Apr., Seite 59-72
1. Verfasser: Min, So-Youn (VerfasserIn)
Weitere Verfasser: Fu, Yuyang, Hutcheson, Jack, Wu, Tianfu, Khobahy, Elhaum, Zhu, Jiankun, Vanarsa, Kamala, Du, Yong, Park, Min-Jung, Park, Hyun-Sil, Saxena, Ramesh, Kim, Ho-Youn, Mohan, Chandra
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2012
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Antigens, Differentiation CD11b Antigen CD5 Antigens Myeloid Differentiation Factor 88 monocyte-macrophage differentiation antigen Interleukin-10 130068-27-8 mehr... Jumonji Domain-Containing Histone Demethylases EC 1.14.11.- Kdm6b protein, mouse EC 1.5.-
Beschreibung
Zusammenfassung:Copyright © 2012 Elsevier Inc. All rights reserved.
Catheters are implanted into the peritoneal cavity during the process of peritoneal dialysis. Though these catheters may be effective and beneficial, the impact of catheters on the immune system is poorly understood. Catheters and other devices implanted in the peritoneal cavity elicit a foreign body reaction. However, the immunological consequences of this remain uncharacterized. To model this, catheters were implanted into the peritoneal cavity of healthy mice. Catheter implantation induced rapid cellular changes within the peritoneal cavity. Whereas B-cells and T-cells were reduced, catheter implantation was associated with the rapid expansion of F4/80-low-positive, CD11b-positive macrophages that elaborated IL-10, and suppressed T-cell division and Th1 skewing in co-culture assays. Peritoneal catheter elicited macrophages had increased Jmjd3 but reduced NF-κB activation, and their emergence was MyD88-dependent. Collectively, these studies indicate that foreign body implantation into the peritoneal cavity is associated with the expansion of suppressor macrophages. Whether peritoneal cavity catheter implantation may have systemic immunoregulatory roles remains to be explored
Beschreibung:Date Completed 11.05.2012
Date Revised 09.10.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2012.01.003