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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/err464
|2 doi
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|a pubmed24n0718.xml
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|a (DE-627)NLM215384717
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|a (NLM)22330898
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Khan, Sabaz Ali
|e verfasserin
|4 aut
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| 245 |
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|a Genetic analysis of metabolites in apple fruits indicates an mQTL hotspot for phenolic compounds on linkage group 16
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| 264 |
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 07.09.2012
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Apple (Malus×domestica Borkh) is among the main sources of phenolic compounds in the human diet. The genetic basis of the quantitative variations of these potentially beneficial phenolic compounds was investigated. A segregating F₁ population was used to map metabolite quantitative trait loci (mQTLs). Untargeted metabolic profiling of peel and flesh tissues of ripe fruits was performed using liquid chromatography-mass spectrometry (LC-MS), resulting in the detection of 418 metabolites in peel and 254 in flesh. In mQTL mapping using MetaNetwork, 669 significant mQTLs were detected: 488 in the peel and 181 in the flesh. Four linkage groups (LGs), LG1, LG8, LG13, and LG16, were found to contain mQTL hotspots, mainly regulating metabolites that belong to the phenylpropanoid pathway. The genetics of annotated metabolites was studied in more detail using MapQTL®. A number of quercetin conjugates had mQTLs on LG1 or LG13. The most important mQTL hotspot with the largest number of metabolites was detected on LG16: mQTLs for 33 peel-related and 17 flesh-related phenolic compounds. Structural genes involved in the phenylpropanoid biosynthetic pathway were located, using the apple genome sequence. The structural gene leucoanthocyanidin reductase (LAR1) was in the mQTL hotspot on LG16, as were seven transcription factor genes. The authors believe that this is the first time that a QTL analysis was performed on such a high number of metabolites in an outbreeding plant species
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Phenols
|2 NLM
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| 650 |
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|a Transcription Factors
|2 NLM
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| 700 |
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|a Chibon, Pierre-Yves
|e verfasserin
|4 aut
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| 700 |
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|a de Vos, Ric C H
|e verfasserin
|4 aut
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| 700 |
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|a Schipper, Bert A
|e verfasserin
|4 aut
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| 700 |
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|a Walraven, Evert
|e verfasserin
|4 aut
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| 700 |
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|a Beekwilder, Jules
|e verfasserin
|4 aut
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| 700 |
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|a van Dijk, Thijs
|e verfasserin
|4 aut
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| 700 |
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|a Finkers, Richard
|e verfasserin
|4 aut
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| 700 |
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|a Visser, Richard G F
|e verfasserin
|4 aut
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| 700 |
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|a van de Weg, Eric W
|e verfasserin
|4 aut
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| 700 |
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|a Bovy, Arnaud
|e verfasserin
|4 aut
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| 700 |
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|a Cestaro, Alessandro
|e verfasserin
|4 aut
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| 700 |
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|a Velasco, Riccardo
|e verfasserin
|4 aut
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| 700 |
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|a Jacobsen, Evert
|e verfasserin
|4 aut
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| 700 |
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|a Schouten, Henk J
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 63(2012), 8 vom: 13. Mai, Seite 2895-908
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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| 773 |
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|g volume:63
|g year:2012
|g number:8
|g day:13
|g month:05
|g pages:2895-908
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| 856 |
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|u http://dx.doi.org/10.1093/jxb/err464
|3 Volltext
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