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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2011.10.006
|2 doi
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|a pubmed24n0711.xml
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|a (DE-627)NLM213419904
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|a (NLM)22122798
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Schneiders, Famke L
|e verfasserin
|4 aut
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|a Activated iNKT cells promote Vγ9Vδ2-T cell anti-tumor effector functions through the production of TNF-α
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 11.04.2012
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|a Date Revised 06.02.2012
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2011 Elsevier Inc. All rights reserved.
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|a Vγ9Vδ2-T cells constitute a proinflammatory lymphocyte subpopulation with established antitumor activity. Phosphoantigens activate Vγ9Vδ2-T cells in vivo and in vitro. We studied whether the antitumor activity of Vγ9Vδ2-T cells can be potentiated by invariant NKT cells (iNKT), an important immunoregulatory T cell subset. When activated by the glycolipid α-galactosylceramide (α-GalCer), iNKT produce large amounts of cytokines involved in antitumor immune responses. Monocyte-derived dendritic cells were loaded with both phosphoantigens (using aminobisphosphonates) and α-GalCer during maturation and subsequently co-cultured with Vγ9Vδ2-T and iNKT cells. Aminobisphosphonates dose-dependently enhanced Vγ9Vδ2-T cell activation, and this was potentiated by α-GalCer-induced iNKT co-activation. iNKT co-activation also enhanced the IFN-γ production and cytolytic potential of Vγ9Vδ2-T cells against tumor cells. Using transwell experiments and neutralizing antibodies cross-talk between iNKT and Vγ9Vδ2-T cells was found to be mediated by TNF-α. Our data provide a rationale for combining both activating ligands to improve Vγ9Vδ2-T cell based approaches in cancer-immunotherapy
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antigens, Neoplasm
|2 NLM
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|a Diphosphonates
|2 NLM
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|a Galactosylceramides
|2 NLM
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|a Hemiterpenes
|2 NLM
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|a Immunologic Factors
|2 NLM
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|a Organophosphorus Compounds
|2 NLM
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|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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|a alpha-galactosylceramide
|2 NLM
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| 650 |
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|a isopentenyl pyrophosphate
|2 NLM
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| 650 |
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|a 358-71-4
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a de Bruin, Renée C G
|e verfasserin
|4 aut
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|a Santegoets, Saskia J A M
|e verfasserin
|4 aut
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| 700 |
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|a Bonneville, Marc
|e verfasserin
|4 aut
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| 700 |
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|a Scotet, Emmanuel
|e verfasserin
|4 aut
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| 700 |
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|a Scheper, Rik J
|e verfasserin
|4 aut
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| 700 |
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|a Verheul, Henk M W
|e verfasserin
|4 aut
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| 700 |
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|a de Gruijl, Tanja D
|e verfasserin
|4 aut
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| 700 |
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|a van der Vliet, Hans J
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 142(2012), 2 vom: 11. Feb., Seite 194-200
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:142
|g year:2012
|g number:2
|g day:11
|g month:02
|g pages:194-200
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|u http://dx.doi.org/10.1016/j.clim.2011.10.006
|3 Volltext
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