|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM212426966 |
| 003 |
DE-627 |
| 005 |
20231224015520.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2012 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2011.08.015
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0708.xml
|
| 035 |
|
|
|a (DE-627)NLM212426966
|
| 035 |
|
|
|a (NLM)22019771
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Moraes-Vieira, Pedro Manoel M
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a GATA3 and a dominant regulatory gene expression profile discriminate operational tolerance in human transplantation
|
| 264 |
|
1 |
|c 2012
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 11.04.2012
|
| 500 |
|
|
|a Date Revised 06.02.2012
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2011 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a Some organ-transplanted patients achieve a state of "operational tolerance" (OT) in which graft function is maintained after the complete withdrawal of immunosuppressive drugs. We used a gene panel of regulatory/inflammatory molecules (FOXP3, GATA3, IL10, TGFB1, TGFBR1/ TBX21, TNF and IFNG) to investigate the gene expression profile in peripheral blood mononuclear cells of renal-transplanted individuals experiencing OT compared to transplanted individuals not displaying OT and healthy individuals (HI). OT subjects showed a predominant regulatory (REG) profile with higher gene expression of GATA3, FOXP3, TGFB1 and TGFB receptor 1 compared to the other groups. This predominant REG gene expression profile displayed stability over time. The significant GATA3 gene and protein expressions in OT individuals suggest that a Th2 deviation may be a relevant pathway to OT. Moreover, the capacity of the REG/INFLAMMA gene panel to discriminate OT by peripheral blood analysis indicates that this state has systemic repercussions
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Multicenter Study
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a FOXP3 protein, human
|2 NLM
|
| 650 |
|
7 |
|a Forkhead Transcription Factors
|2 NLM
|
| 650 |
|
7 |
|a GATA3 Transcription Factor
|2 NLM
|
| 650 |
|
7 |
|a GATA3 protein, human
|2 NLM
|
| 650 |
|
7 |
|a Immunosuppressive Agents
|2 NLM
|
| 650 |
|
7 |
|a Receptors, Transforming Growth Factor beta
|2 NLM
|
| 650 |
|
7 |
|a TGFB1 protein, human
|2 NLM
|
| 650 |
|
7 |
|a Transforming Growth Factor beta1
|2 NLM
|
| 700 |
1 |
|
|a Takenaka, Maisa C S
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Silva, Hernandez M
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Monteiro, Sandra Maria
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Agena, Fabiana
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Lemos, Francine
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Saitovitch, David
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Kalil, Jorge
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Coelho, Verônica
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 142(2012), 2 vom: 15. Feb., Seite 117-26
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:142
|g year:2012
|g number:2
|g day:15
|g month:02
|g pages:117-26
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2011.08.015
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 142
|j 2012
|e 2
|b 15
|c 02
|h 117-26
|