GATA3 and a dominant regulatory gene expression profile discriminate operational tolerance in human transplantation

GATA3 and a dominant regulatory gene expression profile discriminate operational tolerance in human transplantation

Copyright © 2011 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 142(2012), 2 vom: 15. Feb., Seite 117-26
1. Verfasser: Moraes-Vieira, Pedro Manoel M (VerfasserIn)
Weitere Verfasser: Takenaka, Maisa C S, Silva, Hernandez M, Monteiro, Sandra Maria, Agena, Fabiana, Lemos, Francine, Saitovitch, David, Kalil, Jorge, Coelho, Verônica
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2012
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Multicenter Study Research Support, Non-U.S. Gov't FOXP3 protein, human Forkhead Transcription Factors GATA3 Transcription Factor GATA3 protein, human Immunosuppressive Agents Receptors, Transforming Growth Factor beta TGFB1 protein, human Transforming Growth Factor beta1
Beschreibung
Zusammenfassung:Copyright © 2011 Elsevier Inc. All rights reserved.
Some organ-transplanted patients achieve a state of "operational tolerance" (OT) in which graft function is maintained after the complete withdrawal of immunosuppressive drugs. We used a gene panel of regulatory/inflammatory molecules (FOXP3, GATA3, IL10, TGFB1, TGFBR1/ TBX21, TNF and IFNG) to investigate the gene expression profile in peripheral blood mononuclear cells of renal-transplanted individuals experiencing OT compared to transplanted individuals not displaying OT and healthy individuals (HI). OT subjects showed a predominant regulatory (REG) profile with higher gene expression of GATA3, FOXP3, TGFB1 and TGFB receptor 1 compared to the other groups. This predominant REG gene expression profile displayed stability over time. The significant GATA3 gene and protein expressions in OT individuals suggest that a Th2 deviation may be a relevant pathway to OT. Moreover, the capacity of the REG/INFLAMMA gene panel to discriminate OT by peripheral blood analysis indicates that this state has systemic repercussions
Beschreibung:Date Completed 11.04.2012
Date Revised 06.02.2012
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2011.08.015