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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1021/la203249v
|2 doi
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|a pubmed25n0705.xml
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|a (NLM)21939243
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a Liu, Wenjie
|e verfasserin
|4 aut
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|a Facile spray-drying assembly of uniform microencapsulates with tunable core-shell structures and controlled release properties
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 16.02.2012
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Microencapsulates with defined core-shell structures are of interest for applications, such as controlled release and encapsulation, because of the feasibility of fine-tuning individual functionalities of different parts. Here, we report a new approach for efficient and scalable production of such particles. Eudragit RS (a co-polymer of ethyl acrylate, methyl methacrylate, and a low content of methacrylic acid ester with quaternary ammonium groups) was used as the main shell component, with silica as the core component, formed upon a single-step spray-drying assembly. The method is capable of forming uniform core-shell particles from homogeneous precursors without the use of any organic solvents. Evaporation-induced self-assembly attained the phase separation among different components during drying, resulting in the core-shell spatial configuration, while precise control over particle uniformity was accomplished via a microfluidic jet spray dryer. Direct control over shell thickness can be achieved from the ratio of the core and shell ingredients in the precursors. A fluorescent compound, rhodamine B, is used as a highly water-soluble model component to investigate the controlled release properties of these microencapsulates, with the release behaviors shown to be significantly dependent upon their architectures
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Acrylic Resins
|2 NLM
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|a Capsules
|2 NLM
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|a Coated Materials, Biocompatible
|2 NLM
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|a Delayed-Action Preparations
|2 NLM
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|a Silanes
|2 NLM
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|a Water
|2 NLM
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|a 059QF0KO0R
|2 NLM
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|a Eudragit RS
|2 NLM
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|a 33434-24-1
|2 NLM
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|a tetraethoxysilane
|2 NLM
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| 650 |
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|a 42064KRE49
|2 NLM
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| 700 |
1 |
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|a Wu, Winston Duo
|e verfasserin
|4 aut
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|a Selomulya, Cordelia
|e verfasserin
|4 aut
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| 700 |
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|a Chen, Xiao Dong
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 27(2011), 21 vom: 01. Nov., Seite 12910-5
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:27
|g year:2011
|g number:21
|g day:01
|g month:11
|g pages:12910-5
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|u http://dx.doi.org/10.1021/la203249v
|3 Volltext
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