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20231224002103.0 |
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cr uuu---uuuuu |
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231224s2011 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1016/j.clim.2011.03.009
|2 doi
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2 |
|a pubmed24n0691.xml
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|a (DE-627)NLM207444331
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|a (NLM)21489887
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Kuerten, Stefanie
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Myelin-reactive antibodies mediate the pathology of MBP-PLP fusion protein MP4-induced EAE
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| 264 |
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1 |
|c 2011
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 11.08.2011
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| 500 |
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|a Date Revised 15.11.2012
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2011 Elsevier Inc. All rights reserved.
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|a Experimental autoimmune encephalomyelitis (EAE) is frequently used for studies of multiple sclerosis (MS). Because in most EAE models T cells mediate the pathology in the absence of B cells/autoantibodies, the notion has evolved that also MS may be a primarily T cell-mediated disease. We have previously introduced MBP-PLP fusion protein (MP4)-induced EAE in C57BL/6 mice. Here we show that the disease in this model is antibody-dependent. Immunization of B cell-deficient mice did not induce EAE. When such B cell-deficient mice were, however, injected with MBP/PLP-specific antibodies in addition to the immunization with MP4, they developed disease of a severity and course that was similar to the wild-type mice. The deposition of antibodies in demyelinated lesions provided further evidence for the contribution of MBP/PLP-specific antibodies to CNS lesion formation. Based upon these data we suggest a two-stage model for the involvement of MBP/PLP-specific antibodies in autoimmune CNS pathology
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Autoantibodies
|2 NLM
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| 650 |
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7 |
|a Autoantigens
|2 NLM
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| 650 |
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7 |
|a MP4 protein, chimeric
|2 NLM
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| 650 |
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7 |
|a Myelin Basic Protein
|2 NLM
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| 650 |
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7 |
|a Myelin Proteolipid Protein
|2 NLM
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| 650 |
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7 |
|a Recombinant Fusion Proteins
|2 NLM
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| 700 |
1 |
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|a Pauly, Robert
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rottlaender, Andrea
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rodi, Michael
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gruppe, Traugott L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Addicks, Klaus
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tary-Lehmann, Magdalena
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lehmann, Paul V
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 140(2011), 1 vom: 15. Juli, Seite 54-62
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:140
|g year:2011
|g number:1
|g day:15
|g month:07
|g pages:54-62
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2011.03.009
|3 Volltext
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|d 140
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|h 54-62
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