Myelin-reactive antibodies mediate the pathology of MBP-PLP fusion protein MP4-induced EAE

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 140(2011), 1 vom: 15. Juli, Seite 54-62
1. Verfasser:	Kuerten, Stefanie (VerfasserIn)
Weitere Verfasser:	Pauly, Robert, Rottlaender, Andrea, Rodi, Michael, Gruppe, Traugott L, Addicks, Klaus, Tary-Lehmann, Magdalena, Lehmann, Paul V
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2011
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Autoantibodies Autoantigens MP4 protein, chimeric Myelin Basic Protein Myelin Proteolipid Protein Recombinant Fusion Proteins

Beschreibung
Zusammenfassung:	Copyright © 2011 Elsevier Inc. All rights reserved. Experimental autoimmune encephalomyelitis (EAE) is frequently used for studies of multiple sclerosis (MS). Because in most EAE models T cells mediate the pathology in the absence of B cells/autoantibodies, the notion has evolved that also MS may be a primarily T cell-mediated disease. We have previously introduced MBP-PLP fusion protein (MP4)-induced EAE in C57BL/6 mice. Here we show that the disease in this model is antibody-dependent. Immunization of B cell-deficient mice did not induce EAE. When such B cell-deficient mice were, however, injected with MBP/PLP-specific antibodies in addition to the immunization with MP4, they developed disease of a severity and course that was similar to the wild-type mice. The deposition of antibodies in demyelinated lesions provided further evidence for the contribution of MBP/PLP-specific antibodies to CNS lesion formation. Based upon these data we suggest a two-stage model for the involvement of MBP/PLP-specific antibodies in autoimmune CNS pathology
Beschreibung:	Date Completed 11.08.2011 Date Revised 15.11.2012 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2011.03.009