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231223s2011 xx |||||o 00| ||eng c |
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|a 10.1021/la104152s
|2 doi
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|a pubmed25n0682.xml
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|e rakwb
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|a eng
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|a Devi, Usha
|e verfasserin
|4 aut
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|a Pd(II)-mediated assembly of porphyrin channels in bilayer membranes
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 26.05.2011
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a A membrane-spanning bis(meso-3-pyridyl) porphyrin 1 has been synthesized, embedded in EYPC vesicles, and upon Pd(II) addition has been shown to form ionophores that allow the passage of anionic 5/6-carboxyfluorescein through membranes. The geometric matching of bis(meso-3-pyridyl) porphyrin 1 and trans-Pd(II) was designed to give a cyclic porphyrin trimer [PdCl(2)(1)](3). However, solution-phase studies showed that PdCl(2)(PhCN)(2) cross linked 1 into linear oligomers at porphyrin concentrations above 10 mM, although the formation of cyclic species was inferred from studies at concentrations below 2 μM. Fluorescence titrations showed that embedding porphyrin 1 in bilayers greatly reduced its affinity for Pd(II), but the combination of porphyrin 1 and Pd(II) gave an ionophoric species that increased the rate of 5/6-carboxyfluorescein (5/6-CF) transit through the phospholipid bilayer 12-fold. A maximum in the 5/6-CF release rate was observed at a Pd(II) concentration of 4 μM, and the application of a solution-phase binding model to the membrane phase showed that this peak in ionophoric activity corresponded to the greatest extent of porphyrin oligomerization. Further studies suggested these Pd(II)/porphyrin oligomers transported 5/6-CF via a channel mechanism
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Lipid Bilayers
|2 NLM
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|a Porphyrins
|2 NLM
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|a Palladium
|2 NLM
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|a 5TWQ1V240M
|2 NLM
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|a Brown, James R D
|e verfasserin
|4 aut
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|a Almond, Andrew
|e verfasserin
|4 aut
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|a Webb, Simon J
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 27(2011), 4 vom: 15. Feb., Seite 1448-56
|w (DE-627)NLM098181009
|x 1520-5827
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|g volume:27
|g year:2011
|g number:4
|g day:15
|g month:02
|g pages:1448-56
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|u http://dx.doi.org/10.1021/la104152s
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