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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2010.05.010
|2 doi
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|a pubmed25n0664.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Shahbazi, Majid
|e verfasserin
|4 aut
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| 245 |
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|a High frequency of the IL-2 -330 T/HLA-DRB1*1501 haplotype in patients with multiple sclerosis
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|c 2010
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 07.12.2010
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|a Date Revised 17.11.2011
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2010 Elsevier Inc. All rights reserved.
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|a We have evaluated the role of the HLA-DRB1*1501 allele and the IL-2 -330 T/G polymorphism and their interaction in susceptibility to multiple sclerosis on 360 patients and 426 matched healthy individuals. We used the SSP-PCR method to determine the alleles. Fisher's exact test was used to analyses. We observed a significant increase in the T allele at IL-2 -330 position in patients (OR=1.34, P<0.05), and the T/T and T/G genotypes were more frequent among patients than controls. The HLA-DRB1*1501 allele was overrepresented in patients as compared to the control group (OR=1.7, P=0.0006). The two-locus analysis of the interaction between the IL-2 promoter polymorphism and the HLA-DRB1 allele showed that the HLA-DRB1*1501/T haplotype was more frequent in patients than controls (OR=16, P<0.0001). Our findings support previous findings about the role of the HLA-DRB1*1501 allele in susceptibility to MS. This work also provides new findings about the importance of gene-gene interactions in the development of MS
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a HLA-DR Antigens
|2 NLM
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| 650 |
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|a HLA-DRB1 Chains
|2 NLM
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| 650 |
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|a HLA-DRB1*15:01 antigen
|2 NLM
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| 650 |
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|a Interleukin-2
|2 NLM
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| 700 |
1 |
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|a Roshandel, Danial
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ebadi, Hamid
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fathi, Davood
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zamani, Mahdi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Boghaee, Mojdeh
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mohammadhoseeeni, Mana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rshaidbaghan, Azam
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bakhshandeh, Azam
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shahbazi, Saleh
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 137(2010), 1 vom: 01. Okt., Seite 134-8
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
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|g volume:137
|g year:2010
|g number:1
|g day:01
|g month:10
|g pages:134-8
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|u http://dx.doi.org/10.1016/j.clim.2010.05.010
|3 Volltext
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