High frequency of the IL-2 -330 T/HLA-DRB1*1501 haplotype in patients with multiple sclerosis

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 137(2010), 1 vom: 01. Okt., Seite 134-8
1. Verfasser:	Shahbazi, Majid (VerfasserIn)
Weitere Verfasser:	Roshandel, Danial, Ebadi, Hamid, Fathi, Davood, Zamani, Mahdi, Boghaee, Mojdeh, Mohammadhoseeeni, Mana, Rshaidbaghan, Azam, Bakhshandeh, Azam, Shahbazi, Saleh
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2010
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't HLA-DR Antigens HLA-DRB1 Chains HLA-DRB1*15:01 antigen Interleukin-2

Beschreibung
Zusammenfassung:	Copyright © 2010 Elsevier Inc. All rights reserved. We have evaluated the role of the HLA-DRB11501 allele and the IL-2 -330 T/G polymorphism and their interaction in susceptibility to multiple sclerosis on 360 patients and 426 matched healthy individuals. We used the SSP-PCR method to determine the alleles. Fisher's exact test was used to analyses. We observed a significant increase in the T allele at IL-2 -330 position in patients (OR=1.34, P<0.05), and the T/T and T/G genotypes were more frequent among patients than controls. The HLA-DRB11501 allele was overrepresented in patients as compared to the control group (OR=1.7, P=0.0006). The two-locus analysis of the interaction between the IL-2 promoter polymorphism and the HLA-DRB1 allele showed that the HLA-DRB11501/T haplotype was more frequent in patients than controls (OR=16, P<0.0001). Our findings support previous findings about the role of the HLA-DRB11501 allele in susceptibility to MS. This work also provides new findings about the importance of gene-gene interactions in the development of MS
Beschreibung:	Date Completed 07.12.2010 Date Revised 17.11.2011 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2010.05.010