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20231223211059.0 |
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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1021/la101123y
|2 doi
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|a pubmed24n0659.xml
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Jiao, Yong-Hua
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Layer-by-layer assembly of poly(lactic acid) nanoparticles
|b a facile way to fabricate films for model drug delivery
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|c 2010
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 08.09.2010
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|a Date Revised 25.11.2016
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|a published: Print
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|a Citation Status MEDLINE
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|a Layer-by-layer (LBL) films of poly(lactic acid) nanoparticles (PLA NPs) and poly(ethyleneimine) (PEI) were fabricated as a novel drug-delivery system. The PLA NPs, which encapsulated pyrene as a model drug, were prepared by nanoprecipitation methods. The assembly process of PLA NPs/PEI LBL films was monitored by UV-vis spectroscopy, and the load of pyrene in the multilayer films was verified by fluorescence spectroscopy. The morphology of the PLA NPs/PEI LBL films was observed by SEM. The release profile of pyrene from the LBL films in PBS solutions was further studied, and the result indicated that the PLA NPs/PEI films were capable of sustainably releasing pyrene as expected. The fabrication of PLA NPs/PEI LBL films provides a new facile method for drug delivery and paves the way for loading multiple types of drugs into a single LBL film
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Drug Carriers
|2 NLM
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|a Polyesters
|2 NLM
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|a Polymers
|2 NLM
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|a Lactic Acid
|2 NLM
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|a 33X04XA5AT
|2 NLM
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|a poly(lactide)
|2 NLM
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|a 459TN2L5F5
|2 NLM
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| 700 |
1 |
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|a Li, Yan
|e verfasserin
|4 aut
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1 |
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|a Wang, Shu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Kai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jia, Ying-Gang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fu, Yu
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 26(2010), 11 vom: 01. Juni, Seite 8270-3
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:26
|g year:2010
|g number:11
|g day:01
|g month:06
|g pages:8270-3
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|u http://dx.doi.org/10.1021/la101123y
|3 Volltext
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