Layer-by-layer assembly of poly(lactic acid) nanoparticles : a facile way to fabricate films for model drug delivery
Layer-by-layer (LBL) films of poly(lactic acid) nanoparticles (PLA NPs) and poly(ethyleneimine) (PEI) were fabricated as a novel drug-delivery system. The PLA NPs, which encapsulated pyrene as a model drug, were prepared by nanoprecipitation methods. The assembly process of PLA NPs/PEI LBL films was...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1992. - 26(2010), 11 vom: 01. Juni, Seite 8270-3 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2010
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Drug Carriers Polyesters Polymers Lactic Acid 33X04XA5AT poly(lactide) 459TN2L5F5 |
| Zusammenfassung: | Layer-by-layer (LBL) films of poly(lactic acid) nanoparticles (PLA NPs) and poly(ethyleneimine) (PEI) were fabricated as a novel drug-delivery system. The PLA NPs, which encapsulated pyrene as a model drug, were prepared by nanoprecipitation methods. The assembly process of PLA NPs/PEI LBL films was monitored by UV-vis spectroscopy, and the load of pyrene in the multilayer films was verified by fluorescence spectroscopy. The morphology of the PLA NPs/PEI LBL films was observed by SEM. The release profile of pyrene from the LBL films in PBS solutions was further studied, and the result indicated that the PLA NPs/PEI films were capable of sustainably releasing pyrene as expected. The fabrication of PLA NPs/PEI LBL films provides a new facile method for drug delivery and paves the way for loading multiple types of drugs into a single LBL film |
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| Beschreibung: | Date Completed 08.09.2010 Date Revised 25.11.2016 published: Print Citation Status MEDLINE |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/la101123y |