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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1021/la100878s
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|a eng
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|a Janout, Vaclav
|e verfasserin
|4 aut
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|a An upside down view of cholesterol's condensing effect
|b does surface occupancy play a role?
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|c 2010
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|a Text
|b txt
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|a Date Completed 01.07.2010
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|a Date Revised 20.10.2021
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|a published: Print
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|a Citation Status MEDLINE
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|a The condensing action of cholesterol has been compared with that of a structural isomer having its hydroxyl group located at the C-25 position (i.e., 25-OH'), that is, an isomer favoring an "upside down" orientation in lipid membranes. Surface pressure-area isotherms of mixed monolayers made from 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC)/cholesterol and DMPC/25-OH' have established that 25-OH' has a weaker condensing effect than cholesterol. Nearest-neighbor recognition measurements in liposomes made from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) have also shown that 25-OH' has a weaker condensing effect in the physiologically relevant fluid bilayer state. These findings provide support for surface occupancy playing a role in the condensing action of cholesterol
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|a Cholesterol
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|a Turkyilmaz, Serhan
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|a Wang, Minghui
|e verfasserin
|4 aut
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|a Wang, Yao
|e verfasserin
|4 aut
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|a Manaka, Yuichi
|e verfasserin
|4 aut
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|a Regen, Steven L
|e verfasserin
|4 aut
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|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 26(2010), 8 vom: 20. Apr., Seite 5316-8
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