A dual-activation, adenoviral-based system for the controlled induction of DNA double-strand breaks by the restriction endonuclease SacI

Spontaneous damage to DNA is frequent and may lead to cell death, cell senescence, or mutations. DNA double-strand breaks (DSBs) are of special interest because they are highly toxic and have been implicated in neurodegeneration, cancer, and aging. Until now, there has not been a reliable system all...

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Détails bibliographiques
Publié dans:BioTechniques. - 1991. - 47(2009), 4 vom: 23. Okt., Seite 847-54
Auteur principal: Maslov, Alexander Y (Auteur)
Autres auteurs: Metrikin, Maya, Vijg, Jan
Format: Article en ligne
Langue:English
Publié: 2009
Accès à la collection:BioTechniques
Sujets:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Anti-Bacterial Agents Coloring Agents Selective Estrogen Receptor Modulators Tetrazolium Salts Thiazoles Tamoxifen 094ZI81Y45 plus... DNA 9007-49-2 endodeoxyribonuclease SacI EC 3.1.21.- Deoxyribonucleases, Type II Site-Specific EC 3.1.21.4 thiazolyl blue EUY85H477I Doxycycline N12000U13O