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NLM191726443 |
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DE-627 |
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20231223191725.0 |
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cr uuu---uuuuu |
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231223s2009 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1016/j.clim.2009.09.002
|2 doi
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|a pubmed24n0639.xml
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|a (DE-627)NLM191726443
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|a (NLM)19793680
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Walters, Emily
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Estradiol targets T cell signaling pathways in human systemic lupus
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| 264 |
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1 |
|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 22.12.2009
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| 500 |
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a The major risk factor for developing systemic lupus erythematosus (SLE) is being female. The present study utilized gene profiles of activated T cells from females with SLE and healthy controls to identify signaling pathways uniquely regulated by estradiol that could contribute to SLE pathogenesis. Selected downstream pathway genes (+/- estradiol) were measured by real time polymerase chain amplification. Estradiol uniquely upregulated six pathways in SLE T cells that control T cell function including interferon-alpha signaling. Measurement of interferon-alpha pathway target gene expression revealed significant differences (p= 0.043) in DRIP150 (+/- estradiol) in SLE T cell samples while IFIT1 expression was bimodal and correlated moderately (r= 0.55) with disease activity. The results indicate that estradiol alters signaling pathways in activated SLE T cells that control T cell function. Differential expression of transcriptional coactivators could influence estrogen-dependent gene regulation in T cell signaling and contribute to SLE onset and disease pathogenesis
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, N.I.H., Extramural
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| 650 |
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7 |
|a Adaptor Proteins, Signal Transducing
|2 NLM
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| 650 |
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7 |
|a Carrier Proteins
|2 NLM
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| 650 |
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7 |
|a IFIT1 protein, human
|2 NLM
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| 650 |
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7 |
|a MED14 protein, human
|2 NLM
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| 650 |
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7 |
|a Mediator Complex
|2 NLM
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| 650 |
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7 |
|a RNA, Messenger
|2 NLM
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| 650 |
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7 |
|a RNA-Binding Proteins
|2 NLM
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| 650 |
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7 |
|a Estradiol
|2 NLM
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| 650 |
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7 |
|a 4TI98Z838E
|2 NLM
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| 700 |
1 |
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|a Rider, Virginia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Abdou, Nabih I
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Greenwell, Cindy
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Svojanovsky, Stan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Smith, Peter
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kimler, Bruce F
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 133(2009), 3 vom: 01. Dez., Seite 428-36
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:133
|g year:2009
|g number:3
|g day:01
|g month:12
|g pages:428-36
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2009.09.002
|3 Volltext
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|d 133
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|h 428-36
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