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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2009.08.008
|2 doi
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|a pubmed24n0639.xml
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|a (DE-627)NLM191659800
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|a (NLM)19786367
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Wahlström, Jan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Autoimmune T cell responses to antigenic peptides presented by bronchoalveolar lavage cell HLA-DR molecules in sarcoidosis
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|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 22.12.2009
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|a Date Revised 17.11.2011
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The etiology of sarcoidosis remains unknown. Recently, by mass spectrometric sequencing of peptides eluted from HLA-DR molecules of bronchoalveolar lavage (BAL) cells from DRB10301(pos) patients, we identified potential self-antigens in sarcoidosis. The aim of the present study was to investigate the capacity of selected peptides to stimulate lung and blood T cells of sarcoidosis patients using an interferon-gamma ELISPOT assay. In peripheral blood, there were strong T cell responses to a peptide derived from the cytoskeletal protein vimentin in 6 out of 11 DRB10301(pos) patients with active disease but not in patients with other HLA types. BAL T cell responses against peptides derived from ATP synthase or from lysyl-tRNA synthetase were detected in DRB10301(pos) as well as DRB10301(neg) patients. By using antigenic peptides presented in vivo in the lungs of sarcoidosis patients, we have identified blood and lung T cell autoimmune responses that may help sustain the inflammation in this disease
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Autoantibodies
|2 NLM
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| 650 |
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|a HLA-DR Antigens
|2 NLM
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| 650 |
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|a HLA-DRB1 Chains
|2 NLM
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| 650 |
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|a Peptide Fragments
|2 NLM
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| 650 |
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|a Vimentin
|2 NLM
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| 650 |
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|a DNA
|2 NLM
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| 650 |
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|a 9007-49-2
|2 NLM
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| 650 |
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|a Amino Acyl-tRNA Synthetases
|2 NLM
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| 650 |
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|a EC 6.1.1.-
|2 NLM
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| 700 |
1 |
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|a Dengjel, Jörn
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Winqvist, Ola
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Targoff, Ira
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Persson, Bengt
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Duyar, Hüseyin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rammensee, Hans-Georg
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Eklund, Anders
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Weissert, Robert
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Grunewald, Johan
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 133(2009), 3 vom: 01. Dez., Seite 353-63
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:133
|g year:2009
|g number:3
|g day:01
|g month:12
|g pages:353-63
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2009.08.008
|3 Volltext
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|h 353-63
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