Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1

Interferon-beta is a current treatment for multiple sclerosis (MS). Interferon-beta is thought to exert its therapeutic effects on MS by down-modulating the immune response by multiple potential pathways. Here, we document that treatment of MS patients with interferon beta-1a (Rebif) results in a si...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 133(2009), 1 vom: 17. Okt., Seite 27-44
1. Verfasser:	Christophi, George P (VerfasserIn)
Weitere Verfasser:	Panos, Michael, Hudson, Chad A, Tsikkou, Chriso, Mihai, Cornelia, Mejico, Luis J, Jubelt, Burk, Massa, Paul T
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2009
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Cytokines NF-kappa B RNA, Small Interfering STAT1 Transcription Factor STAT1 protein, human STAT6 Transcription Factor STAT6 protein, human mehr... Interferon-beta 77238-31-4 Protein Tyrosine Phosphatase, Non-Receptor Type 6 EC 3.1.3.48 Interferon beta-1a XRO4566Q4R