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DE-627 |
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20231223183307.0 |
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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2009.05.011
|2 doi
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| 028 |
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|a pubmed24n0631.xml
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|a (DE-627)NLM189233745
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|a (NLM)19520616
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhou, Ying
|e verfasserin
|4 aut
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| 245 |
1 |
2 |
|a T cell CD40LG gene expression and the production of IgG by autologous B cells in systemic lupus erythematosus
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| 264 |
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|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 01.09.2009
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| 500 |
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a CD40 ligand (CD40LG), encoded on the X chromosome, has been reported to be overexpressed on lupus T cells. Herein, we investigated the effect of DNA demethylation on T cell CD40LG expression and the production of IgG by autologous B cells in lupus. We found normal human T cells transfected with CD40LG induced autologous B cell activation and plasma cell differentiation. Both female lupus CD4+ T cells and demethylating agents treated CD4+ T cells overexpressed CD40LG mRNA. Further, lupus T cells from both genders or demethylated CD4+ T cells from healthy women overstimulated autologous B cells, and this could be reversed with anti-CD40LG Ab in only females. We demonstrated that female lupus CD4+ T cells and demethylated CD4+ T cells express high level of CD40LG and overstimulate B cells to produce IgG. This is due to DNA demethylation and thereby reactivation of the inactive X chromosome in female
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antibodies, Monoclonal
|2 NLM
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| 650 |
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7 |
|a Antigens, CD
|2 NLM
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| 650 |
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7 |
|a Enzyme Inhibitors
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin G
|2 NLM
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| 650 |
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7 |
|a Lipopolysaccharides
|2 NLM
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| 650 |
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7 |
|a CD40 Ligand
|2 NLM
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| 650 |
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7 |
|a 147205-72-9
|2 NLM
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| 700 |
1 |
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|a Yuan, Jun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pan, Yujun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fei, Yiping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qiu, Xiangning
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Nan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Yongqi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lei, Wenzhi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Yaping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Long, Hai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sawalha, Amr H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Richardson, Bruce
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Qianjin
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 132(2009), 3 vom: 15. Sept., Seite 362-70
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:132
|g year:2009
|g number:3
|g day:15
|g month:09
|g pages:362-70
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2009.05.011
|3 Volltext
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|d 132
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|h 362-70
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