Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions : a potent therapeutic tool for Th1- and/or Th17-mediated skin inflammation

Tim-3 is a cell surface molecule preferentially expressed in Th1 and Th17 cells. Galectin-9 is a ligand for Tim-3 and the binding of galectin-9 to Tim-3 induces apoptosis. We recently developed a stable form of galectin-9 (sGal-9) by partial deletion of the linker peptide. In this study, we characte...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 132(2009), 2 vom: 03. Aug., Seite 184-94
1. Verfasser:	Niwa, Haruna (VerfasserIn)
Weitere Verfasser:	Satoh, Takahiro, Matsushima, Yuki, Hosoya, Kazuki, Saeki, Kazumi, Niki, Toshiro, Hirashima, Mitsuomi, Yokozeki, Hiroo
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2009
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Chemokines Cytokines Galectins Havcr2 protein, mouse Hepatitis A Virus Cellular Receptor 2 Interleukin-17 Interleukin-23 Ligands Receptors, Virus mehr... galectin 9, mouse Croton Oil 8001-28-3 Dinitrofluorobenzene D241E059U6