Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions : a potent therapeutic tool for Th1- and/or Th17-mediated skin inflammation
Tim-3 is a cell surface molecule preferentially expressed in Th1 and Th17 cells. Galectin-9 is a ligand for Tim-3 and the binding of galectin-9 to Tim-3 induces apoptosis. We recently developed a stable form of galectin-9 (sGal-9) by partial deletion of the linker peptide. In this study, we characte...
Ausführliche Beschreibung
Bibliographische Detailangaben
Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 132(2009), 2 vom: 03. Aug., Seite 184-94
|
1. Verfasser: |
Niwa, Haruna
(VerfasserIn) |
Weitere Verfasser: |
Satoh, Takahiro,
Matsushima, Yuki,
Hosoya, Kazuki,
Saeki, Kazumi,
Niki, Toshiro,
Hirashima, Mitsuomi,
Yokozeki, Hiroo |
Format: | Online-Aufsatz
|
Sprache: | English |
Veröffentlicht: |
2009
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Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.)
|
Schlagworte: | Journal Article
Chemokines
Cytokines
Galectins
Havcr2 protein, mouse
Hepatitis A Virus Cellular Receptor 2
Interleukin-17
Interleukin-23
Ligands
Receptors, Virus
mehr...
galectin 9, mouse
Croton Oil
8001-28-3
Dinitrofluorobenzene
D241E059U6 |