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20231223181504.0 |
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cr uuu---uuuuu |
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231223s2009 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2009.03.531
|2 doi
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2 |
|a pubmed24n0627.xml
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|a (DE-627)NLM188194541
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|a (NLM)19406689
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Kassu, Afework
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Decreased 4-1BB expression on HIV-specific CD4+ T cells is associated with sustained viral replication and reduced IL-2 production
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|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 17.09.2009
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| 500 |
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a CD4+ T cell dysfunction in subjects with chronic HIV infection is in part due to an imbalance of costimulatory and coinhibitory receptors. We report that virus-specific CD4+ T cells expressing 4-1BB (CD137) or OX40 (CD134) produced more IL-2 than cells lacking these costimulatory receptors (P<0.05) and that 4-1BB was expressed at a lower level on HIV- than CMV-specific IFN-gamma and IL-2 producing CD4+ T cells (P<0.0001 and P<0.01, respectively). Suppression of viral replication with antiretroviral therapy was associated with increased 4-1BB expression on HIV- and CMV-specific IL-2 producing CD4+ T cells (P<0.05 and P<0.01, respectively) and the percentage of IL-2 producing HIV-specific CD4+ T cells that expressed 4-1BB was inversely correlated with HIV plasma viral load (r=-0.75, P=0.007). These findings indicate that the loss of 4-1BB on HIV-specific CD4+ T cells is associated with viral replication and that it may contribute to reduced IL-2 production observed during chronic infection
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, N.I.H., Extramural
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a 4-1BB Ligand
|2 NLM
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| 650 |
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7 |
|a Interleukin-2
|2 NLM
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| 650 |
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7 |
|a OX40 Ligand
|2 NLM
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| 650 |
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7 |
|a Receptors, OX40
|2 NLM
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| 650 |
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7 |
|a TNFRSF4 protein, human
|2 NLM
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| 650 |
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7 |
|a TNFRSF9 protein, human
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor Receptor Superfamily, Member 9
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a D'Souza, Michelle
|e verfasserin
|4 aut
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| 700 |
1 |
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|a O'Connor, Brian P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kelly-McKnight, Elizabeth
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Akkina, Ramesh
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fontenot, Andrew P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Palmer, Brent E
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 132(2009), 2 vom: 15. Aug., Seite 234-45
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:132
|g year:2009
|g number:2
|g day:15
|g month:08
|g pages:234-45
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2009.03.531
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 132
|j 2009
|e 2
|b 15
|c 08
|h 234-45
|