1H NMR discrimination of CHF4226.01 diastereoisomers in DMSO-d6
2009 John Wiley & Sons, Ltd.
| Publié dans: | Magnetic resonance in chemistry : MRC. - 1985. - 47(2009), 7 vom: 15. Juli, Seite 551-61 |
|---|---|
| Auteur principal: | |
| Autres auteurs: | , , , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2009
|
| Accès à la collection: | Magnetic resonance in chemistry : MRC |
| Sujets: | Comparative Study Journal Article Amphetamines Bronchodilator Agents Hydroxyquinolines carmoterol 9810NUL4D1 Dimethyl Sulfoxide YOW8V9698H |
| Résumé: | 2009 John Wiley & Sons, Ltd. Two diastereoisomers CHF4226.01 (R, R) and CHF4232.01 (S, R), differing for a chiral center, have been studied to investigate their possible discrimination using NMR. 1D NMR and 2D NMR experiments, such as COSY, NOESY and ROESY, were performed on pure isomers and on the association complexes formed in the presence of the chiral reagent (S)-(-)-1-(2-napthyl)ethylamine (S-NEA). Moreover, computational studies, concerning conformational analysis and molecular dynamics, were started and supported the NMR results |
|---|---|
| Description: | Date Completed 12.08.2009 Date Revised 20.11.2014 published: Print Citation Status MEDLINE |
| ISSN: | 1097-458X |
| DOI: | 10.1002/mrc.2427 |