Flexible low-cost system for small animal aerosol inhalation exposure to drugs, proteins, inflammatory agents, and infectious agents

The design for a simple, low-cost aerosol generation system for rodent inhalation studies is described here. This system is appropriate for low biohazard-level agents. In this study, two biosafety level 2 agents, Pasturella pneumotropica and Pseudomonas aeruginosa, were tested successfully. This sys...

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Veröffentlicht in:BioTechniques. - 1993. - 46(2009), 3 Suppl vom: 01. März, Seite Piii-Pviii
1. Verfasser: Schroeder, William G (VerfasserIn)
Weitere Verfasser: Mitrescu, Laura M, Hart, Marcia L, Unnithan, Ranjana, Gilchrist, John M, Smith, Erin E, Shanley, Crystal, Benedict, Katharine M, Taraba, Lauren, Volckens, John, Basaraba, Randall J, Schenkel, Alan R
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:BioTechniques
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Aerosols Ovalbumin 9006-59-1
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520 |a The design for a simple, low-cost aerosol generation system for rodent inhalation studies is described here. This system is appropriate for low biohazard-level agents. In this study, two biosafety level 2 agents, Pasturella pneumotropica and Pseudomonas aeruginosa, were tested successfully. This system was also used to immunize mice and guinea pigs in ovalbumin-based models of pulmonary inflammation. This design is appropriate for studies with limited budgets and lower-level biosafety containment 
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650 4 |a Research Support, Non-U.S. Gov't 
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700 1 |a Mitrescu, Laura M  |e verfasserin  |4 aut 
700 1 |a Hart, Marcia L  |e verfasserin  |4 aut 
700 1 |a Unnithan, Ranjana  |e verfasserin  |4 aut 
700 1 |a Gilchrist, John M  |e verfasserin  |4 aut 
700 1 |a Smith, Erin E  |e verfasserin  |4 aut 
700 1 |a Shanley, Crystal  |e verfasserin  |4 aut 
700 1 |a Benedict, Katharine M  |e verfasserin  |4 aut 
700 1 |a Taraba, Lauren  |e verfasserin  |4 aut 
700 1 |a Volckens, John  |e verfasserin  |4 aut 
700 1 |a Basaraba, Randall J  |e verfasserin  |4 aut 
700 1 |a Schenkel, Alan R  |e verfasserin  |4 aut 
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