Flexible low-cost system for small animal aerosol inhalation exposure to drugs, proteins, inflammatory agents, and infectious agents

Flexible low-cost system for small animal aerosol inhalation exposure to drugs, proteins, inflammatory agents, and infectious agents

The design for a simple, low-cost aerosol generation system for rodent inhalation studies is described here. This system is appropriate for low biohazard-level agents. In this study, two biosafety level 2 agents, Pasturella pneumotropica and Pseudomonas aeruginosa, were tested successfully. This sys...

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Bibliographische Detailangaben
Veröffentlicht in:BioTechniques. - 1993. - 46(2009), 3 Suppl vom: 01. März, Seite Piii-Pviii
1. Verfasser: Schroeder, William G (VerfasserIn)
Weitere Verfasser: Mitrescu, Laura M, Hart, Marcia L, Unnithan, Ranjana, Gilchrist, John M, Smith, Erin E, Shanley, Crystal, Benedict, Katharine M, Taraba, Lauren, Volckens, John, Basaraba, Randall J, Schenkel, Alan R
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:BioTechniques
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Aerosols Ovalbumin 9006-59-1
Beschreibung
Zusammenfassung:The design for a simple, low-cost aerosol generation system for rodent inhalation studies is described here. This system is appropriate for low biohazard-level agents. In this study, two biosafety level 2 agents, Pasturella pneumotropica and Pseudomonas aeruginosa, were tested successfully. This system was also used to immunize mice and guinea pigs in ovalbumin-based models of pulmonary inflammation. This design is appropriate for studies with limited budgets and lower-level biosafety containment
Beschreibung:Date Completed 21.05.2009
Date Revised 25.03.2009
published: Print
Citation Status MEDLINE
ISSN:1940-9818
DOI:10.2144/000112895