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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1021/la802696j
|2 doi
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|a pubmed24n0620.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Aoki, P H B
|e verfasserin
|4 aut
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| 245 |
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|a Layer-by-layer technique as a new approach to produce nanostructured films containing phospholipids as transducers in sensing applications
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|c 2009
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 31.03.2009
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|a Date Revised 09.03.2009
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|a published: Print
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|a Citation Status MEDLINE
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|a Phospholipids are widely used as mimetic systems to exploit interactions involving biological membranes and pharmacological drugs. In this work, the layer-by-layer (LbL) technique was used as a new approach to produce multilayered thin films containing biological phospholipids applied as transducers onto Pt interdigitated electrodes forming sensing units of an electronic tongue system. Low concentrations (nM level) of a phenothiazine compound were detected through impedance spectroscopy. Both negative 1,2-dipalmitoyl-sn-3-glycero-[phosphor-rac-(1-glycerol)] (DPPG) and zwitterionic l-alpha-1,2-dipalmitoyl-sn-3-glycero-phosphatidylcholine (DPPC) phospholipids were used to produce the LbL films, whose molecular architecture was monitored combining spectroscopy and microscopy at micro and nanoscales. The sensor array was complemented by Langmuir-Blodgett (LB) monolayers of DPPG and DPPC deposited onto Pt interdigitated electrodes as well. It was found that the distinct molecular architecture presented by both LbL and LB films plays a key role on the sensitivity of the sensor array with the importance of the LbL films being demonstrated by principal component analysis (PCA)
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Pharmaceutical Preparations
|2 NLM
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|a Phospholipids
|2 NLM
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1 |
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|a Volpati, D
|e verfasserin
|4 aut
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1 |
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|a Riul, A
|c Jr
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Caetano, W
|e verfasserin
|4 aut
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|a Constantino, C J L
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 25(2009), 4 vom: 17. Feb., Seite 2331-8
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:25
|g year:2009
|g number:4
|g day:17
|g month:02
|g pages:2331-8
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|u http://dx.doi.org/10.1021/la802696j
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