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NLM185335713 |
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DE-627 |
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20231223172315.0 |
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tu |
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231223s2008 xx ||||| 00| ||chi c |
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|a pubmed24n0618.xml
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|a (DE-627)NLM185335713
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|a (NLM)19099826
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Zhang, Hong-yu
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Association between SNAP-25 gene polymorphism and attention deficit hyperactivity disorder
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| 264 |
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|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 02.12.2010
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|a Date Revised 07.06.2016
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To analyse the association between polymorphism in human synaptosomal-associated protein of 25 000 (SNAP-25) gene and attention deficit hyperactivity disorder (ADHD) in Han Chinese children
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|a METHODS: The study samples were comprised of 100 integrated ADHD trios (included proband and biological parents) and 97 unrelated controls. Association of polymorphism with ADHD and its subtype was examined by: (1) comparing cases and controls; (2) using family-based association study in transmission disequilibrium test (TDT)
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|a RESULTS: Case-control analysis of short tandem repeat (STR) showed that there was no significant difference between the two groups in allele gene frequency and genotype frequency (P > 0.05); TDT analysis of the rs363006 SNP and the rs362549 SNP revealed no association between SNAP-25 polymorphisms and ADHD (P > 0.05). But after a stratification by ADHD subtype, the rs362549 SNP A allele showed a tendency to preferentially transmitted to ADHD-I subtype (chi(2) = 8.00, P < 0.01); and the rs362549 SNP G allele had a tendency to preferentially transmitted to ADHD-C subtype (chi(2) = 4.122, P < 0.05)
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|a CONCLUSIONS: No association was found between SNAP-25 polymorphisms and ADHD. There was a possible association between rs362549 SNP polymorphism and ADHD subtypes, but the findings require replication before drawing a definitive conclusion
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|a English Abstract
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a SNAP25 protein, human
|2 NLM
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| 650 |
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7 |
|a Synaptosomal-Associated Protein 25
|2 NLM
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| 700 |
1 |
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|a Zhu, Yan-bo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chang, Hong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Jia-chang
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 46(2008), 8 vom: 22. Aug., Seite 564-9
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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| 773 |
1 |
8 |
|g volume:46
|g year:2008
|g number:8
|g day:22
|g month:08
|g pages:564-9
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|a AR
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|d 46
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|h 564-9
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