Association between SNAP-25 gene polymorphism and attention deficit hyperactivity disorder
OBJECTIVE: To analyse the association between polymorphism in human synaptosomal-associated protein of 25 000 (SNAP-25) gene and attention deficit hyperactivity disorder (ADHD) in Han Chinese children
| Veröffentlicht in: | Zhonghua er ke za zhi = Chinese journal of pediatrics. - 1960. - 46(2008), 8 vom: 22. Aug., Seite 564-9 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , |
| Format: | Aufsatz |
| Sprache: | Chinese |
| Veröffentlicht: |
2008
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| Zugriff auf das übergeordnete Werk: | Zhonghua er ke za zhi = Chinese journal of pediatrics |
| Schlagworte: | English Abstract Journal Article Research Support, Non-U.S. Gov't SNAP25 protein, human Synaptosomal-Associated Protein 25 |
| Zusammenfassung: | OBJECTIVE: To analyse the association between polymorphism in human synaptosomal-associated protein of 25 000 (SNAP-25) gene and attention deficit hyperactivity disorder (ADHD) in Han Chinese children METHODS: The study samples were comprised of 100 integrated ADHD trios (included proband and biological parents) and 97 unrelated controls. Association of polymorphism with ADHD and its subtype was examined by: (1) comparing cases and controls; (2) using family-based association study in transmission disequilibrium test (TDT) RESULTS: Case-control analysis of short tandem repeat (STR) showed that there was no significant difference between the two groups in allele gene frequency and genotype frequency (P > 0.05); TDT analysis of the rs363006 SNP and the rs362549 SNP revealed no association between SNAP-25 polymorphisms and ADHD (P > 0.05). But after a stratification by ADHD subtype, the rs362549 SNP A allele showed a tendency to preferentially transmitted to ADHD-I subtype (chi(2) = 8.00, P < 0.01); and the rs362549 SNP G allele had a tendency to preferentially transmitted to ADHD-C subtype (chi(2) = 4.122, P < 0.05) CONCLUSIONS: No association was found between SNAP-25 polymorphisms and ADHD. There was a possible association between rs362549 SNP polymorphism and ADHD subtypes, but the findings require replication before drawing a definitive conclusion |
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| Beschreibung: | Date Completed 02.12.2010 Date Revised 07.06.2016 published: Print Citation Status MEDLINE |
| ISSN: | 0578-1310 |